Ontology highlight
ABSTRACT:
SUBMITTER: Perez JC
PROVIDER: S-EPMC2649204 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Perez J Christian JC Groisman Eduardo A EA
Proceedings of the National Academy of Sciences of the United States of America 20090227 11
Evolutionary changes in ancestral regulatory circuits can bring about phenotypic differences between related organisms. Studies of regulatory circuits in eukaryotes suggest that these modifications result primarily from changes in cis-regulatory elements (as opposed to alterations in the transcription factors that act upon these sequences). It is presently unclear how the evolution of gene regulatory circuits has proceeded in bacteria, given the rampant effects of horizontal gene transfer, which ...[more]