Microparticle-associated endothelial protein C receptor and the induction of cytoprotective and anti-inflammatory effects.

ABSTRACT:

Background

The endothelial protein C receptor plays an important role within the protein C pathway in regulating coagulation and inflammation. Recently, we described that endothelial protein C receptor can be released in vitro in microparticulate form from primary endothelial cells by exogenous activated protein C. Activated protein C bound to this endothelial protein C receptor retains anticoagulant activity and we hypothesize that this microparticulate endothelial protein C receptor-activated protein C complex can also cleave endothelial protease-activated receptor 1 to modulate inflammation and increase cell survival. Our main objective was, therefore, to study the effect that microparticle-associated endothelial protein C receptor-activated protein C has on endothelial function

SUBMITTER: Perez-Casal M 

PROVIDER: S-EPMC2649352 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature