Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response.

ABSTRACT: There are clinical parallels between the nature and course of depressive symptoms in major depressive disorder (MDD) and those of inflammatory disorders. However, the characterization of a possible immune system dysregulation in MDD has been challenging. Emerging data support the role of T-cell dysfunction. Here we report the association of MDD and antidepressant response to genes important in the modulation of the hypothalamic-pituitary-adrenal axis and immune functions in Mexican Americans with major depression. Specifically, single nucleotide polymorphisms (SNPs) in two genes critical for T-cell function are associated with susceptibility to MDD: PSMB4 (proteasome beta4 subunit), important for antigen processing, and TBX21 (T bet), critical for differentiation. Our analyses revealed a s

SUBMITTER: Wong ML 

PROVIDER: S-EPMC2650233 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature