Transmission networks of drug resistance acquired in primary/early stage HIV infection.

ABSTRACT:

Objectives

Population-based sequencing of primary/recent HIV infections (PHIs) can provide a framework for understanding transmission dynamics of local epidemics. In Quebec, half of PHIs represent clustered transmission events. This study ascertained the cumulative implications of clustering on onward transmission of drug resistance.

Methods

HIV-1 pol sequence datasets were available for all genotyped PHI (<6 months postseroconversion; n = 848 subtype B infections, 1997-2007). Phylogenetic analysis established clustered transmission events, based on maximum likelihood topologies having high bootstrap values (>98%) and short genetic distances. The distributions of resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors and protease inhibitors in unique and

SUBMITTER: Brenner BG 

PROVIDER: S-EPMC2650396 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature