Gene expression profiling of experimental saccular aneurysms using deoxyribonucleic acid microarrays.

ABSTRACT:

Background and purpose

The molecular characteristics of the pathophysiology of saccular aneurysms remain poorly understood. The purpose of the current study was to investigate the expression of various groups of genes at different stages of aneurysm age in elastase-induced saccular aneurysms in rabbits through the use of deoxyribonucleic acid (DNA) microarrays.

Materials and methods

A microarray consisting of genes related to cell adhesion, apoptosis, cell signaling, growth, inflammation, vascular remodeling, and oxidative stress was constructed by using rabbit nucleotide sequences. Elastase-induced saccular aneurysms were created at the origin of the right common carotid artery (CCA) in 12 rabbits. Two weeks (n=6) and 12 weeks (n=6) after aneurysm creation, ribonucleic acid

SUBMITTER: Kadirvel R 

PROVIDER: S-EPMC2650496 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature