Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.

ABSTRACT:

Purpose

MicroRNAs (miRNA) are a class of small noncoding RNA molecules that have been implicated in a wide variety of basic cellular functions through posttranscriptional regulations on their target genes. Compelling evidence has shown that miRNAs are involved in cancer initiation and progression. We hypothesized that genetic variations of the miRNA machinery genes could be associated with the risk of renal cell carcinoma.

Experimental design

We genotyped 40 single nucleotide polymorphisms (SNP) from 11 miRNA processing genes (DROSHA, DGCR8, XPO5, RAN, DICER1, TARBP2, AGO1, AGO2, GEMIN3, GEMIN4, HIWI) and 15 miRNA genes in 279 Caucasian patients with renal cell carcinoma and 278 matched controls.

Results

We found that two SNPs in the GEMIN4 gene were significantly ass

SUBMITTER: Horikawa Y 

PROVIDER: S-EPMC2650498 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature