Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1.

ABSTRACT: The target of rapamycin (TOR) kinase coordinately regulates fundamental metabolic and cellular processes to support growth, proliferation, survival, and differentiation, and consequently it has been proposed as a therapeutic target for the treatment of cancer, metabolic disease, and aging. The TOR kinase is found in two biochemically and functionally distinct complexes, termed TORC1 and TORC2. Aided by the compound rapamycin, which specifically inhibits TORC1, the role of TORC1 in regulating translation and cellular growth has been extensively studied. The physiological roles of TORC2 have remained largely elusive due to the lack of pharmacological inhibitors and its genetic lethality in mammals. Among potential targets of TORC2, the pro-survival kinase AKT has garnered much attention. Wit

SUBMITTER: Jones KT 

PROVIDER: S-EPMC2650726 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature