A functional and regulatory network associated with PIP expression in human breast cancer.

ABSTRACT:

Background

The PIP (prolactin-inducible protein) gene has been shown to be expressed in breast cancers, with contradictory results concerning its implication. As both the physiological role and the molecular pathways in which PIP is involved are poorly understood, we conducted combined gene expression profiling and network analysis studies on selected breast cancer cell lines presenting distinct PIP expression levels and hormonal receptor status, to explore the functional and regulatory network of PIP co-modulated genes.

Principal findings

Microarray analysis allowed identification of genes co-modulated with PIP independently of modulations resulting from hormonal treatment or cell line heterogeneity. Relevant clusters of genes that can discriminate between [PIP+] and [PIP-]

SUBMITTER: Debily MA 

PROVIDER: S-EPMC2650800 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature