Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects.

ABSTRACT: PlexinD1 is a membrane-bound receptor that mediates signals derived from class 3 secreted semaphorins. Although semaphorin signaling in axon guidance in the nervous system has been extensively studied, functions outside the nervous system including important roles in vascular patterning have also been demonstrated. Inactivation of plexinD1 leads to neo-natal lethality, structural defects of the cardiac outflow tract, peripheral vascular abnormalities, and axial skeletal morphogenesis defects. PlexinD1 is expressed by vascular endothelial cells, but additional domains of expression have also been demonstrated including in lymphocytes, osteoblasts, neural crest and the central nervous system. Hence, the cell-type specific functions of plexinD1 have remained unclear. Here, we describe the res

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC2650856 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature