Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network.

ABSTRACT: Significant insight about biological networks arises from the study of network motifs--overly abundant network subgraphs--but such wiring patterns do not specify when and how potential routes within a cellular network are used. To address this limitation, we introduce activity motifs, which capture patterns in the dynamic use of a network. Using this framework to analyze transcription in Saccharomyces cerevisiae metabolism, we find that cells use different timing activity motifs to optimize transcription timing in response to changing conditions: forward activation to produce metabolic compounds efficiently, backward shutoff to rapidly stop production of a detrimental product and synchronized activation for co-production of metabolites required for the same reaction. Measuring protein abun

SUBMITTER: Chechik G 

PROVIDER: S-EPMC2651818 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature