Comparative kinomics of human and chimpanzee reveal unique kinship and functional diversity generated by new domain combinations.

ABSTRACT:

Background

Phosphorylation by protein kinases is a common event in many cellular processes. Further, many kinases perform specialized roles and are regulated by non-kinase domains tethered to kinase domain. Perturbation in the regulation of kinases leads to malignancy. We have identified and analysed putative protein kinases encoded in the genome of chimpanzee which is a close evolutionary relative of human.

Result

The shared core biology between chimpanzee and human is characterized by many orthologous protein kinases which are involved in conserved pathways. Domain architectures specific to chimp/human kinases have been observed. Chimp kinases with unique domain architectures are characterized by deletion of one or more non-kinase domains in the human kinases. Interestingl

SUBMITTER: Anamika K 

PROVIDER: S-EPMC2651890 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature