Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation.

ABSTRACT:

Background

Cells transformed by human adenoviruses (Ad) exhibit differential capacities to induce tumours in immunocompetent rodents; for example, Ad12-transformed rodent cells are oncogenic whereas Ad5-transformed cells are not. The E1A gene determines oncogenic phenotype, is a transcriptional regulator and dysregulates host cell gene expression, a key factor in both cellular transformation and oncogenesis. To reveal differences in gene expression between cells transformed with oncogenic and non-oncogenic adenoviruses we have performed comparative analysis of transcript profiles with the aim of identifying candidate genes involved in the process of neoplastic transformation.

Results

Analysis of microarray data revealed that a total of 232 genes were differentially expressed

SUBMITTER: Strath J 

PROVIDER: S-EPMC2651901 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature