Using cell fate attractors to uncover transcriptional regulation of HL60 neutrophil differentiation.

ABSTRACT:

Background

The process of cellular differentiation is governed by complex dynamical biomolecular networks consisting of a multitude of genes and their products acting in concert to determine a particular cell fate. Thus, a systems level view is necessary for understanding how a cell coordinates this process and for developing effective therapeutic strategies to treat diseases, such as cancer, in which differentiation plays a significant role. Theoretical considerations and recent experimental evidence support the view that cell fates are high dimensional attractor states of the underlying molecular networks. The temporal behavior of the network states progressing toward different cell fate attractors has the potential to elucidate the underlying molecular mechanisms governing diffe

SUBMITTER: Huang AC 

PROVIDER: S-EPMC2652435 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature