Performance of BRCA1/2 mutation prediction models in Asian Americans.

ABSTRACT:

Purpose

There are established differences in breast cancer epidemiology between Asian and white individuals, but little is known about hereditary breast cancer in Asian populations. Although increasing numbers of Asian individuals are clinically tested for BRCA1/2 mutations, it is not known whether computer models that predict mutations work accurately in Asian individuals. We compared the performance in Asian and white individuals of two widely used BRCA1/2 mutation prediction models, BRCAPRO and Myriad II.

Patients and methods

We evaluated BRCAPRO and Myriad II in 200 Asian individuals and a matched control group of 200 white individuals who were tested for BRCA1/2 mutations at four cancer genetics clinics, by comparing numbers of observed versus predicted mutation carrier

SUBMITTER: Kurian AW 

PROVIDER: S-EPMC2653135 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature