Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease.

ABSTRACT:

Aim

To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease.

Methods

Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals.

Results

Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003), folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not o

SUBMITTER: Hadithi M 

PROVIDER: S-EPMC2653396 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature