Evolution of multiple phosphodiesterase isoforms in stickleback involved in cAMP signal transduction pathway.

ABSTRACT:

Background

Duplicate genes are considered to have evolved through the partitioning of ancestral functions among duplicates (subfunctionalization) and/or the acquisition of novel functions from a beneficial mutation (neofunctionalization). Additionally, an increase in gene dosage resulting from duplication may also confer an advantageous effect, as has been suggested for histone, tRNA, and rRNA genes. Currently, there is little understanding of the effect of increased gene dosage on subcellular networks like signal transduction pathways. Addressing this issue may provide further insights into the evolution by gene duplication.

Results

We analyzed the evolution of multiple stickleback phosphodiesterase (PDE, EC: 3.1.4.17) 1C genes involved in the cyclic nucleotide signaling pa

SUBMITTER: Sato Y 

PROVIDER: S-EPMC2653465 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature