Probiotic Lactobacillus reuteri biofilms produce antimicrobial and anti-inflammatory factors.

ABSTRACT:

Background

Commensal-derived probiotic bacteria inhibit enteric pathogens and regulate host immune responses in the gastrointestinal tract, but studies examining specific functions of beneficial microbes in the context of biofilms have been limited in scope.

Results

Lactobacillus reuteri formed biofilms that retained functions potentially advantageous to the host including modulation of cytokine output and the production of the antimicrobial agent, reuterin. Immunomodulatory activities of biofilms were demonstrated by the abilities of specific L. reuteri strains to suppress human TNF production by LPS-activated monocytoid cells. Quantification of the antimicrobial glycerol derivative, reuterin, was assessed in order to document the antipathogenic potential of probiotic biofi

SUBMITTER: Jones SE 

PROVIDER: S-EPMC2653509 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature