Genome-wide analysis of chicken snoRNAs provides unique implications for the evolution of vertebrate snoRNAs.

ABSTRACT:

Background

Small nucleolar RNAs (snoRNAs) represent one of the largest groups of functionally diverse trans-acting non-protein-coding (npc) RNAs currently known in eukaryotic cells. Chicken snoRNAs have been very poorly characterized when compared to other vertebrate snoRNAs. A genome-wide analysis of chicken snoRNAs is therefore of great importance to further understand the functional evolution of snoRNAs in vertebrates.

Results

Two hundred and one gene variants encoding 93 box C/D and 62 box H/ACA snoRNAs were identified in the chicken genome and are predicted to guide 86 2'-O-ribose methylations and 69 pseudouridylations of rRNAs and spliceosomal RNAs. Forty-four snoRNA clusters were grouped into four categories based on synteny characteristics of the clustered snoRNAs be

SUBMITTER: Shao P 

PROVIDER: S-EPMC2653536 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature