Global gene expression analysis reveals reduced abundance of putative microRNA targets in human prostate tumours.

ABSTRACT:

Background

Recently, microRNAs (miRNAs) have taken centre stage in the field of human molecular oncology. Several studies have shown that miRNA profiling analyses offer new possibilities in cancer classification, diagnosis and prognosis. However, the function of miRNAs that are dysregulated in tumours remains largely a mystery. Global analysis of miRNA-target gene expression has helped illuminate the role of miRNAs in developmental gene expression programs, but such an approach has not been reported in cancer transcriptomics.

Results

In this study, we globally analysed the expression patterns of miRNA target genes in prostate cancer by using several public microarray datasets. Intriguingly, we found that, in contrast to global mRNA transcript levels, putative miRNA targets s

SUBMITTER: Sun R 

PROVIDER: S-EPMC2653538 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature