Ontology highlight
ABSTRACT:
SUBMITTER: Baggs JE
PROVIDER: S-EPMC2653556 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Baggs Julie E JE Price Tom S TS DiTacchio Luciano L Panda Satchidananda S Fitzgerald Garret A GA Hogenesch John B JB
PLoS biology 20090301 3
The mammalian circadian clock is a cell-autonomous system that drives oscillations in behavior and physiology in anticipation of daily environmental change. To assess the robustness of a human molecular clock, we systematically depleted known clock components and observed that circadian oscillations are maintained over a wide range of disruptions. We developed a novel strategy termed Gene Dosage Network Analysis (GDNA) in which small interfering RNA (siRNA)-induced dose-dependent changes in gene ...[more]