Selective survival and maturation of adult-born dentate granule cells expressing the immediate early gene Arc/Arg3.1.

ABSTRACT: Progenitor cells in the adult dentate gyrus provide a constant supply of neuronal precursors, yet only a small fraction of these cells survive and develop into mature dentate granule cells (DGCs). A major challenge of current research is thus to understand the stringent selection process that governs the maturation and functional integration of adult-born DGCs. In mature DGCs, high-frequency stimulation (HFS) of the perforant path input elicits robust expression of the immediate early gene Arc/Arg3.1, trafficking of its mRNA to dendrites, and local synthesis of the protein necessary for consolidation of long-term potentiation (LTP). Given the synaptic commitment inherent in LTP consolidation, we considered that HFS-evoked expression of Arc could be used to timemap the functional integratio

SUBMITTER: Kuipers SD 

PROVIDER: S-EPMC2654102 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature