The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes.

ABSTRACT:

Background

Genetic and biological evidence supports a role for DISC1 across a spectrum of major mental illnesses, including schizophrenia and bipolar disorder. There is evidence for genetic interplay between variants in DISC1 and in biologically interacting loci in psychiatric illness. DISC1 also associates with normal variance in behavioral and brain imaging phenotypes.

Methodology

Here, we analyze public domain datasets and demonstrate correlations between variants in the DISC1 pathway genes and levels of gene expression. Genetic variants of DISC1, NDE1, PDE4B and PDE4D regulate the expression of cytoskeletal, synaptogenic, neurodevelopmental and sensory perception proteins. Interestingly, these regulated genes include existing targets for drug development in depression an

SUBMITTER: Hennah W 

PROVIDER: S-EPMC2654149 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature