Invariant natural killer T cells suppress the neutrophil inflammatory response in a mouse model of cholestatic liver damage.

ABSTRACT:

Background & aims

NK1.1(+) TCRalphabeta(int) CD1-restricted T (NKT) cells are a unique subset of T lymphocytes that are believed to have an immunoregulatory role in a wide range of diseases. Most mouse NKT cells express a T-cell receptor that contains an invariant Valpha14Jalpha18 chain and recognizes antigenic glycolipids presented in association with major histocompatibility complex class Ib (CD1d) molecules. These invariant NKT (iNKT) cells have been implicated in cholestatic liver injury.

Methods

We examined the role of iNKT cells in liver injury associated with biliary obstruction in mice with ligations of the common bile duct.

Results

The number of activated iNKT cells increased markedly in the livers of mice following bile duct ligation. Plasma alanine aminotra

SUBMITTER: Wintermeyer P 

PROVIDER: S-EPMC2654188 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature