Serum estradiol concentration as a predictor of death in critically ill and injured adults.

ABSTRACT:

Background

Whereas animal models of sepsis demonstrate survival benefits for the pro-estrus state, human observational studies have failed to demonstrate a consistent survival advantage among female patients. Estrogen biosynthesis differs substantially in primate and non-primate animals, and estrogens have diverse immunologic actions. Estrogen concentrations are elevated in response to critical illness and injury (regardless of sex), and elevated concentrations of serum estradiol are associated with a higher mortality rate. Our objective was to determine the predictive ability and test characteristics of the serum estradiol concentration at 48 h in critically ill patients.

Methods

A prospective cohort study of surgical and trauma adult intensive care unit patients at two aca

SUBMITTER: Dossett LA 

PROVIDER: S-EPMC2654258 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature