High levels of endogenous estrogens are associated with death in the critically injured adult.

ABSTRACT:

Background

Sex hormones exhibit predictable changes in their physiologic patterns during critical illness. Endogenous estrogens are elevated in both genders as a result of the peripheral conversion of androgens to estrogens by the aromatase enzyme. Elevated endogenous estrogens have been associated with death in medical and mixed surgical intensive care unit (ICU) patients. Our objective was to determine the relationship between endogenous estrogens and outcomes in critically injured patients.

Methods

A prospective cohort of injured patients remaining in the ICU for at least 48 hours at two trauma centers was enrolled. Sex hormones (estradiol, progesterone, testosterone, prolactin, and dehydroepiandrosterone-sulfate) were assayed and mortality was assessed. A logistic regres

SUBMITTER: Dossett LA 

PROVIDER: S-EPMC2654263 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature