Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis.

ABSTRACT:

Purpose

Substantial evidence implicates insulin-like growth factor-I (IGF-I) signaling in the development and progression of breast cancer. To more clearly elucidate the role of IGF in human breast cancer, we identified and then examined gene expression patterns of IGF-I-treated breast cancer cells.

Methods

MCF-7 cells were stimulated with IGF-I for 3 or 24 hours and were profiled for greater than 22,000 RNA transcripts. We defined an IGF-I signature pattern of more than 800 genes that were up- or downregulated at both time points. The gene signature was examined in clinical breast tumors and in experimental models that represented other oncogenic pathways. The signature was correlated with clinical and pathologic variables and with patient outcome.

Results

IGF-I caus

SUBMITTER: Creighton CJ 

PROVIDER: S-EPMC2654368 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature