Prognostic utility of the 21-gene assay in hormone receptor-positive operable breast cancer compared with classical clinicopathologic features.

ABSTRACT:

Purpose

Adjuvant! is a standardized validated decision aid that projects outcomes in operable breast cancer based on classical clinicopathologic features and therapy. Genomic classifiers offer the potential to more accurately identify individuals who benefit from chemotherapy than clinicopathologic features.

Patients and methods

A sample of 465 patients with hormone receptor (HR) -positive breast cancer with zero to three positive axillary nodes who did (n = 99) or did not have recurrence after chemohormonal therapy had tumor tissue evaluated using a 21-gene assay. Histologic grade and HR expression were evaluated locally and in a central laboratory.

Results

Recurrence Score (RS) was a highly significant predictor of recurrence, including node-negative and node-positi

SUBMITTER: Goldstein LJ 

PROVIDER: S-EPMC2654377 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature