Crosstalk between the androgen receptor and beta-catenin in castrate-resistant prostate cancer.

ABSTRACT: The androgen-signaling pathway plays an important role in the development and hormonal progression of prostate cancer to the castrate-resistant stage (also called androgen-independent or hormone refractory). The Wnt pathway and beta-catenin contribute to prostate biology and pathology. Here application of Affymetrix GeneChip analysis revealed the genomic similarity of the LNCaP hollow fiber model to clinical samples and identified genes with differential expression during hormonal progression. The fiber model samples clustered according to the expression profile of androgen-regulated genes to provide genomic evidence for the reactivation of the AR signaling pathway in castrate-resistant prostate cancer. Pathway-based characterization of gene expression identified activation of the Wnt path

SUBMITTER: Wang G 

PROVIDER: S-EPMC2654418 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature