Polymorphisms of glutathione-S-transferase M1, T1, P1 and the risk of prostate cancer: a case-control study.

ABSTRACT:

Background

It has been suggested that polymorphisms in glutathione-S-transferases (GST) could predispose to prostate cancer through a heritable deficiency in detoxification pathways for environmental carcinogens. Yet, studies linking GST polymorphism and prostate cancer have so far failed to unambiguously establish this relation in patients. A retrospective study on healthy, unrelated subjects was conducted in order to estimate the population GST genotype frequencies in the Slovak population of men and compare our results with already published data (GSEC project-Genetic Susceptibility to Environmental Carcinogens). A further aim of the study was to evaluate polymorphisms in GST also in patients with prostate cancer in order to compare the evaluated proportions with those found in

SUBMITTER: Sivonova M 

PROVIDER: S-EPMC2654432 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature