Genome-wide gene expression analysis reveals a dynamic interplay between luteotropic and luteolytic factors in the regulation of corpus luteum function in the bonnet monkey (Macaca radiata).

ABSTRACT: Although LH is essential for survival and function of the corpus luteum (CL) in higher primates, luteolysis occurs during nonfertile cycles without a discernible decrease in circulating LH levels. Using genome-wide expression analysis, several experiments were performed to examine the processes of luteolysis and rescue of luteal function in monkeys. Induced luteolysis with GnRH receptor antagonist (Cetrorelix) resulted in differential regulation of 3949 genes, whereas replacement with exogenous LH (Cetrorelix plus LH) led to regulation of 4434 genes (1563 down-regulation and 2871 up-regulation). A model system for prostaglandin (PG) F(2alpha)-induced luteolysis in the monkey was standardized and demonstrated that PGF(2alpha) regulated expression of 2290 genes in the CL. Analysis of the LH-

SUBMITTER: Priyanka S 

PROVIDER: S-EPMC2654745 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature