Robust simplifications of multiscale biochemical networks.

ABSTRACT:

Background

Cellular processes such as metabolism, decision making in development and differentiation, signalling, etc., can be modeled as large networks of biochemical reactions. In order to understand the functioning of these systems, there is a strong need for general model reduction techniques allowing to simplify models without loosing their main properties. In systems biology we also need to compare models or to couple them as parts of larger models. In these situations reduction to a common level of complexity is needed.

Results

We propose a systematic treatment of model reduction of multiscale biochemical networks. First, we consider linear kinetic models, which appear as "pseudo-monomolecular" subsystems of multiscale nonlinear reaction networks. For such linear mode

SUBMITTER: Radulescu O 

PROVIDER: S-EPMC2654786 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature