Genome and gene alterations by insertions and deletions in the evolution of human and chimpanzee chromosome 22.

ABSTRACT:

Background

Understanding structure and function of human genome requires knowledge of genomes of our closest living relatives, the primates. Nucleotide insertions and deletions (indels) play a significant role in differentiation that underlies phenotypic differences between humans and chimpanzees. In this study, we evaluated distribution, evolutionary history, and function of indels found by comparing syntenic regions of the human and chimpanzee genomes.

Results

Specifically, we identified 6,279 indels of 10 bp or greater in a ~33 Mb alignment between human and chimpanzee chromosome 22. After the exclusion of those in repetitive DNA, 1,429 or 23% of indels still remained. This group was characterized according to the local or genome-wide repetitive nature, size, location rel

SUBMITTER: Volfovsky N 

PROVIDER: S-EPMC2654908 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature