Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol.

ABSTRACT: A region along chromosome 7q was recently linked to components of the metabolic syndrome (MetS) in several genome-wide linkage studies. Within this region, the CD36 gene, which encodes a membrane receptor for long-chain fatty acids and lipoproteins, is a potentially important candidate. CD36 has been documented to play an important role in fatty acid metabolism in vivo and subsequently may be involved in the etiology of the MetS. The protein also impacts survival to malaria and the influence of natural selection has resulted in high CD36 genetic variability in populations of African descent. We evaluated 36 tag SNPs across CD36 in the HyperGen population sample of 2020 African-Americans for impact on the MetS and its quantitative traits. Five SNPs associated with increased odds for the Met

SUBMITTER: Love-Gregory L 

PROVIDER: S-EPMC2655228 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature