Fiber tractography reveals disruption of temporal lobe white matter tracts in schizophrenia.

ABSTRACT: Diffusion tensor imaging (DTI) studies have demonstrated abnormal anisotropic diffusion in schizophrenia. However, examining data with low spatial resolution and/or a low number of gradient directions and limitations associated with analysis approaches sensitive to registration confounds may have contributed to mixed findings concerning the regional specificity and direction of results. This study examined three major white matter tracts connecting lateral and medial temporal lobe regions with neocortical association regions widely implicated in systems-level functional and structural disturbances in schizophrenia. Using DTIstudio, a previously validated regions of interest tractography method was applied to 30 direction diffusion weighted imaging data collected from demographically simila

SUBMITTER: Phillips OR 

PROVIDER: S-EPMC2655322 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature