Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis.

ABSTRACT: Tailoring steps are often important for the activity of mature antibiotics. Here, we report that novel decarboxylated FR-008/candicidin derivatives were obtained from the P450 monooxygenase gene fscP mutant of Streptomyces sp. strain FR-008. The toxicity of decarboxylated FR-008/candicidin derivatives has been shown to be greatly reduced compared to that of wild-type FR-008/candicidin.

SUBMITTER: Chen S 

PROVIDER: S-EPMC2655452 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature