Transcriptional regulation of the cellobiose operon of Streptococcus mutans.

ABSTRACT: The ability of Streptococcus mutans to catabolize cellobiose, a beta-linked glucoside generated during the hydrolysis of cellulose, is shown to be regulated by a transcriptional regulator, CelR, which is encoded by an operon with a phospho-beta-glucosidase (CelA) and a cellobiose-specific sugar phosphotransferase system (PTS) permease (EII(Cel)). The roles of CelR, EII(Cel) components, and certain fructose/mannose-PTS permeases in the transcriptional regulation of the cel locus were analyzed. The results revealed that (i) the celA and celB (EIIB(Cel)) gene promoters require CelR for transcriptional activation in response to cellobiose, but read-through from the celA promoter contributes to expression of the EII(Cel) genes; (ii) the EII(Cel) subunits were required for growth on cellobiose a

SUBMITTER: Zeng L 

PROVIDER: S-EPMC2655531 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature