The CiaR response regulator in group B Streptococcus promotes intracellular survival and resistance to innate immune defenses.

ABSTRACT: Group B Streptococcus (GBS) is major cause of invasive disease in newborn infants and the leading cause of neonatal meningitis. To gain access to the central nervous system (CNS), GBS must not only subvert host defenses in the bloodstream but also invade and survive within brain microvascular endothelial cells (BMEC), the principal cell layer composing the blood-brain barrier (BBB). While several GBS determinants that contribute to the invasion of BMEC have been identified, little is known about the GBS factors that are required for intracellular survival and ultimate disease progression. In this study we sought to identify these factors by screening a random GBS mutant library in an in vitro survival assay. One mutant was identified which contained a disruption in a two-component regulato

SUBMITTER: Quach D 

PROVIDER: S-EPMC2655536 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature