Coinfection with two closely related alphaherpesviruses results in a highly diversified recombination mosaic displaying negative genetic interference.

ABSTRACT: Phylogenetic studies of the emergence and spread of natural recombinants in herpesviruses infecting humans and animals have been reported recently. However, despite an ever-increasing amount of evidence of recombination in herpesvirus history, the recombination process and the consequences on the genetic diversity of the progeny remain poorly characterized. We addressed this issue by using multiple single-nucleotide polymorphisms (SNPs) differentiating the two subtypes of an alphaherpesvirus, bovine herpesvirus 1 (BoHV-1). Analysis of a large sample of progeny virions obtained in a single growth cycle of coinfected BoHV-1 strains provided a prospective investigation of the recombination dynamics by using SNPs as recombination markers. We found that the simultaneous infection with two close

SUBMITTER: Muylkens B 

PROVIDER: S-EPMC2655596 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature