Dynamic histone variant exchange accompanies gene induction in T cells.

ABSTRACT: Changes in chromatin composition are often a prerequisite for gene induction. Nonallelic histone variants have recently emerged as key players in transcriptional control and chromatin modulation. While the changes in chromatin accessibility and histone posttranslational modification (PTM) distribution that accompany gene induction are well documented, the dynamics of histone variant exchange that parallel these events are still poorly defined. In this study, we have examined the changes in histone variant distribution that accompany activation of the inducible CD69 and heparanase genes in T cells. We demonstrate that the chromatin accessibility increases that accompany the induction of both of these genes are not associated with nucleosome loss but instead are paralleled by changes in hist

SUBMITTER: Sutcliffe EL 

PROVIDER: S-EPMC2655607 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature