Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis.

ABSTRACT:

Introduction

Treatment with sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been shown to be efficacious in the MRL/lpr and NZB x NZW F1 mouse models of lupus nephritis, indicating a critical role for the mTOR pathway in both models. This type of demonstration of efficacy in animal models is usually a pre-requisite for advancement into clinical development. However, efficacy in an animal model often has not translated to the desired activity in the clinic. Therefore, a more profound understanding of the mechanistic similarities and differences between various animal models and human diseases is highly desirable.

Methods

Transcriptional profiling was performed on kidneys from mice with lupus nephritis; from mice who had efficacious drug treatment; and from mi

SUBMITTER: Reddy PS 

PROVIDER: S-EPMC2656226 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature