Analysis of small nucleolar RNAs reveals unique genetic features in malaria parasites.

ABSTRACT:

Background

Ribosome biogenesis is an energy consuming and stringently controlled process that involves hundreds of trans-acting factors. Small nucleolar RNAs (snoRNAs), important components of ribosome biogenesis are non-coding guide RNAs involved in rRNA processing, nucleotide modifications like 2'-O-ribose methylation, pseudouridylation and possibly gene regulation. snoRNAs are ubiquitous and are diverse in their genomic organization, mechanism of transcription and process of maturation. In vertebrates, most snoRNAs are present in introns of protein coding genes and are processed by exonucleolytic cleavage, while in plants they are transcribed as polycistronic transcripts.

Results

This is a comprehensive analysis of malaria parasite snoRNA genes and proteins that have a ro

SUBMITTER: Mishra PC 

PROVIDER: S-EPMC2656528 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature