MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment.

ABSTRACT: The mucin 1 (MUC1) oncoprotein is aberrantly overexpressed in human breast cancers. Although MUC1 modulates the activity of estrogen receptor alpha (ER), there is no information regarding the effects of MUC1 on global gene expression patterns and the potential role of MUC1-induced genes in predicting outcome for breast cancer patients. We have developed an experimental model of MUC1-induced transformation that has identified the activation of genes involved in cholesterol and fatty acid metabolism. A 38-gene set of experimentally derived MUC1-induced genes associated with lipid metabolism was applied to the analysis of ER(+) breast cancer patients treated with tamoxifen. The results obtained from 2 independent databases demonstrate that patients overexpressing MUC1 and the lipid metabolic

SUBMITTER: Pitroda SP 

PROVIDER: S-EPMC2656554 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature