Detection of genetic association and a functional polymorphism of dynamin 1 gene with nicotine dependence in European and African Americans.

ABSTRACT: Although it has been documented that dynamin 1 gene (DNM1) is significantly modulated by nicotine in animal models, its association with nicotine dependence (ND) in human population remained to be unexplored. To determine whether DNM1 is associated with ND, in this study, we genotyped seven single-nucleotide polymorphisms (SNPs) within this gene in 602 nuclear families of either African-American (AA) or European-American (EA) origin. Individual SNP-based association analysis revealed a significant association of SNP rs3003609 with smoking quantity (SQ; P=0.0031) and Heaviness of Smoking Index (HSI; P=0.0042) in the EA sample. Furthermore, our haplotype-based association analyses indicated that haplotypes T-G-T, formed by rs2502731-rs2229917-rs3003609 (at a frequency of 54%), G-T-A, formed

SUBMITTER: Xu Q 

PROVIDER: S-EPMC2656577 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature