PAI-1 and functional blockade of SNAI1 in breast cancer cell migration.

ABSTRACT:

Introduction

Snail, a family of transcriptional repressors implicated in cell movement, has been correlated with tumour invasion. The Plasminogen Activation (PA) system, including urokinase plasminogen activator (uPA), its receptor and its inhibitor, plasminogen activator inhibitor type 1(PAI-1), also plays a key role in cancer invasion and metastasis, either through proteolytic degradation or by non-proteolytic modulation of cell adhesion and migration. Thus, Snail and the PA system are both over-expressed in cancer and influence this process. In this study we aimed to determine if the activity of SNAI1 (a member of the Snail family) is correlated with expression of the PA system components and how this correlation can influence tumoural cell migration.

Methods

We compared

SUBMITTER: Fabre-Guillevin E 

PROVIDER: S-EPMC2656896 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature