The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.

ABSTRACT:

Introduction

Common variants that alter breast cancer risk are being discovered. Here, we determine how these variants influence breast cancer prognosis, risk and tumour characteristics.

Methods

We selected 1,001 women with early onset nonfamilial invasive breast cancer from the Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) cohort and genotyped 206 single nucleotide polymorphisms (SNPs) across 30 candidate genes. After quality control, 899 cases and 133 SNPs remained. Survival analyses were used to identify SNPs associated with prognosis and determine their interdependency with recognized prognostic factors. To identify SNPs that alter breast cancer risk, association tests were used to compare cases with controls from the Wellcome Trust Cas

SUBMITTER: Tapper W 

PROVIDER: S-EPMC2656905 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature