A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish.

ABSTRACT:

Background

In mammals, the members of the tripartite motif (TRIM) protein family are involved in various cellular processes including innate immunity against viral infection. Viruses exert strong selective pressures on the defense system. Accordingly, antiviral TRIMs have diversified highly through gene expansion, positive selection and alternative splicing. Characterizing immune TRIMs in other vertebrates may enlighten their complex evolution.

Results

We describe here a large new subfamily of TRIMs in teleosts, called finTRIMs, identified in rainbow trout as virus-induced transcripts. FinTRIMs are formed of nearly identical RING/B-box regions and C-termini of variable length; the long variants include a B30.2 domain. The zebrafish genome harbors a striking diversity of finT

SUBMITTER: van der Aa LM 

PROVIDER: S-EPMC2657112 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature