Antiplatelet drugs for prevention of pre-eclampsia and its consequences: systematic review.

ABSTRACT:

Objective

To assess the effectiveness and safety of antiplatelet drugs for prevention of pre-eclampsia and its consequences.

Design

Systematic review.

Data sources

Register of trials maintained by Cochrane Pregnancy and Childbirth Group, Cochrane Controlled Trials Register, and Embase.

Included studies

Randomised trials involving women at risk of pre-eclampsia, and its complications, allocated to antiplatelet drug(s) versus placebo or no antiplatelet drug.

Main outcome measures

Pre-eclampsia, preterm birth, fetal or neonatal death, and small for gestational age baby. Studies were assessed for quality of concealment of allocation and losses to follow up.

Results

39 trials (30 563 women) were included, and 45 trials (>3000 women) excluded. Use of an

SUBMITTER: Duley L 

PROVIDER: S-EPMC26574 | biostudies-literature | 2001 Feb

REPOSITORIES: biostudies-literature