Enhancement of periprosthetic bone quality with topical hydroxyapatite-bisphosphonate composite.

ABSTRACT:

Background

Implant loosening is associated with inflammatory bone loss induced by ultra-high molecular weight polyethylene wear debris. We hypothesized that a hydroxyapatite-bisphosphonate composite improves periprosthetic bone quality and osseous integration of an intramedullary implant even in the presence of ultra-high molecular weight polyethylene particles in an experimental rat femur model.

Methods

A preliminary in vitro study determined the optimal concentration of zoledronate (50 microM) that would maximally decrease osteoclasts without harming osteoblasts. Hydroxyapatite-coated intramedullary nails were implanted bilaterally in the femora of sixteen rats (the control group), and hydroxyapatite-zoledronate-coated nails were implanted bilaterally in the femora of sixt

SUBMITTER: Suratwala SJ 

PROVIDER: S-EPMC2657477 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature