Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation.

ABSTRACT: The insulin and insulin-like growth factor 1 receptors activate overlapping signalling pathways that are critical for growth, metabolism, survival and longevity. Their mechanism of ligand binding and activation displays complex allosteric properties, which no mathematical model has been able to account for. Modelling these receptors' binding and activation in terms of interactions between the molecular components is problematical due to many unknown biochemical and structural details. Moreover, substantial combinatorial complexity originating from multivalent ligand binding further complicates the problem. On the basis of the available structural and biochemical information, we develop a physically plausible model of the receptor binding and activation, which is based on the concept of a h

SUBMITTER: Kiselyov VV 

PROVIDER: S-EPMC2657531 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature