Catheter-directed gastric artery chemical embolization suppresses systemic ghrelin levels in porcine model.

ABSTRACT:

Purpose

To prospectively test, in a porcine model, the hypothesis that catheter-directed gastric artery chemical embolization (GACE) can result in suppression of systemic ghrelin levels and affect weight gain.

Materials and methods

This study, which had Animal Care and Use Committee approval, was performed in healthy, growing swine (weight range, 40-45 kg; n = 10). GACE was performed in five swine with the infusion of sodium morrhuate (125 mug) selectively into the gastric arteries that supply the fundus. Five control animals underwent a sham procedure with 5 mL of saline. Weight and fasting plasma ghrelin levels were obtained in animals at baseline and in weeks 1-4. Statistical testing for substantial differences in ghrelin blood levels over time and between treated and unt

SUBMITTER: Arepally A 

PROVIDER: S-EPMC2657856 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature